Exploration into conolidine has triggered discovery of the opioid receptor in the body known as ACKR3/CXCR7. ACKR3 is apparently the most sought after target for conolidine, which also disregards the other four classical opioid receptors(3). There's fascination in employing conolidine for a pain-reliever determined by proof from animal investigation https://www.proleviate.com/post/conolidine-an-alternative-natural-pain-relief-to-replace-traditional-painkillers