Environmental or self-antigens and homotypic interactions bring about BCR and Toll-like receptor (TLR) signaling, amplifying the response of CLL cells to other signals within the microenvironment and raising the activation of anti-apoptotic and proliferation pathways.31,32 Genomic reports have discovered recurrent mutations in genes regulating tumor mobile-microenvironment interaction... https://juliusr652oyg0.bloggerchest.com/profile