Pentobarbital will reduce the extent or influence of pioglitazone by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Small/Significance Not known. pentobarbital will lower the extent or effect of atazanavir by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Minimal/Significance Not known. Induction of microsomal enzymes by this drug, could shorten the 50 percent-lifetime... https://torreyd789ohv9.answerblogs.com/profile