Cigarette smoking cigarettes decreases amounts of promethazine by raising metabolism. Use Warning/Check. Interaction predominantly viewed w/chlorpromazine & thioridazine, but may well come about w/other phenothiazines. chlorpromazine will lower the extent or influence of codeine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Observe. Stops conversion of codeine to its Ener... https://wockusa.com/product-category/anti-cancer/