Gastrointestinal (GI): NSAIDs that block COX-one action have correlations with GI issues because of the inhibition of the synthesis of gastroprotective agents for instance PGE2 together with other prostaglandins. This inhibition contributes to reduced mucin creation by gastric epithelial cells, a lot less bicarbonate secretion, and fewer epithelial cell turnover, https://nielse776zmr6.robhasawiki.com/user